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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
AP2A1
All Species:
40.91
Human Site:
Y250
Identified Species:
81.82
UniProt:
O95782
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O95782
NP_570603.2
977
107546
Y250
D
L
Q
D
Y
T
Y
Y
F
V
P
A
P
W
L
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001115458
977
107553
Y250
D
L
Q
D
Y
T
Y
Y
F
V
P
A
P
W
L
Dog
Lupus familis
XP_541490
922
101289
K239
A
Q
E
P
P
K
S
K
K
V
Q
H
S
N
A
Cat
Felis silvestris
Mouse
Mus musculus
P17426
977
107646
Y250
D
L
Q
D
Y
T
Y
Y
F
V
P
A
P
W
L
Rat
Rattus norvegicus
P18484
938
104026
Y250
D
L
Q
D
Y
T
Y
Y
F
V
P
A
P
W
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
NP_001012914
938
104174
Y250
D
L
Q
D
Y
T
Y
Y
F
V
P
A
P
W
L
Frog
Xenopus laevis
NP_001089303
939
104392
Y250
D
L
Q
D
Y
T
Y
Y
F
V
P
A
P
W
L
Zebra Danio
Brachydanio rerio
XP_001922441
959
106027
Y250
D
L
Q
D
Y
T
Y
Y
F
V
P
A
P
W
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P91926
940
105602
Y249
D
L
Q
D
Y
T
Y
Y
F
V
P
A
P
W
L
Honey Bee
Apis mellifera
XP_394621
937
104937
Y249
D
L
Q
D
Y
T
Y
Y
F
V
P
A
P
W
L
Nematode Worm
Caenorhab. elegans
NP_509572
925
104161
Y249
D
L
Q
D
Y
T
Y
Y
F
V
P
A
P
W
L
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P38065
1025
114993
A291
F
P
L
E
Y
T
F
A
N
M
P
N
P
W
L
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
99.5
91.3
N.A.
98.4
79.4
N.A.
N.A.
79.5
78.3
82.1
N.A.
66.6
68
62.2
N.A.
Protein Similarity:
100
N.A.
99.8
92.7
N.A.
98.8
86.9
N.A.
N.A.
87.4
87
88.1
N.A.
77.8
78.8
74.9
N.A.
P-Site Identity:
100
N.A.
100
6.6
N.A.
100
100
N.A.
N.A.
100
100
100
N.A.
100
100
100
N.A.
P-Site Similarity:
100
N.A.
100
13.3
N.A.
100
100
N.A.
N.A.
100
100
100
N.A.
100
100
100
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
23.7
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
44.3
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
40
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
60
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
9
0
0
0
0
0
0
9
0
0
0
84
0
0
9
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
84
0
0
84
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
9
9
0
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
9
0
0
0
0
0
9
0
84
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
9
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
9
0
9
9
0
0
0
0
0
0
% K
% Leu:
0
84
9
0
0
0
0
0
0
0
0
0
0
0
92
% L
% Met:
0
0
0
0
0
0
0
0
0
9
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
9
0
0
9
0
9
0
% N
% Pro:
0
9
0
9
9
0
0
0
0
0
92
0
92
0
0
% P
% Gln:
0
9
84
0
0
0
0
0
0
0
9
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
0
0
0
0
0
9
0
0
0
0
0
9
0
0
% S
% Thr:
0
0
0
0
0
92
0
0
0
0
0
0
0
0
0
% T
% Val:
0
0
0
0
0
0
0
0
0
92
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
92
0
% W
% Tyr:
0
0
0
0
92
0
84
84
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _